ICANCER ESEARCH34,986990,May1974] Patterns of Excretion of Methylated Purines in Hepatocellular Carcinoma
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چکیده
The quantities of total and free guanine, adenine, hypoxanthine, and six of their methylated derivatives and of 6-succinoaminopurine have been measured in urine speci mens from cases of hepatocellular carcinoma and cirrhosis of the liver, and from normal subjects. Total base was defined as the sum of the free purine plus the increment released by means of acid hydrolysis. Analyses were per formed with an improved paper Chromatographie technique described in this report. Differences associated with hepatoma were best shown in the concentrations of total and bound purine relative to creatinine. On the average, total 7-methylguanine, 1-methylguanine, A/2-dimethylguanine, 1-
منابع مشابه
Patterns of excretion of methylated purines in hepatocellular carcinoma.
The quantities of total and free guanine, adenine, hypoxanthine, and six of their methylated derivatives and of 6-succinoaminopurine have been measured in urine speci mens from cases of hepatocellular carcinoma and cirrhosis of the liver, and from normal subjects. Total base was defined as the sum of the free purine plus the increment released by means of acid hydrolysis. Analyses were per form...
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